Plasma Adrenomedullin and Subclinical Cardiorenal Syndrome in Patients with Type 2 Diabetes Mellitus

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8249" target="_blank" >RIV/00064203:_____/12:8249 - isvavai.cz</a>
Alternative codes found
RIV/00023761:_____/12:#0000230 RIV/00216208:11130/12:8249
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pubmed/22971508" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/22971508</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Plasma Adrenomedullin and Subclinical Cardiorenal Syndrome in Patients with Type 2 Diabetes Mellitus
Original language description
OBJECTIVE: To evaluate whether plasma adrenomedullin is involved in the previously reported significant inverse correlation between left ventricular (LV) end-diastolic pressure (peak velocity of early transmitral flow/peak velocity of early diastolic mitral annular motion ratio [E/E']) and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus, mild-to-moderate renal function impairment and LV relaxation impairment (E' <= 7.1 cm/s). METHODS: Plasma adrenomedullin concentration, E/E' and eGFR were assessed in 82 patients with type 2 diabetes. RESULTS: Plasma adrenomedullin concentration was positively correlated with eGFR in patients with or without LV relaxation impairment, and inversely correlated with E/E' in patients with LV relaxation impairment. Multivariate linear regression analysis supported a role for plasma adrenomedullin in the association between E/E' and eGFR. CONCLUSION: These results support the hypothesis that adrenomedullin modulates the
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
<a href="/en/project/NR9520" target="_blank" >NR9520: Diastolic dysfunction in diabetes mellitus II.type. The significance of the selected clinical, metabolic and endocrine parameters</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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