p16(INK4a) Immunoprofiles of Squamous Lesions of the Uterine Cervix-Implications for the Reclassification of Atypical Immature Squamous Metaplasia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F13%3A10209713" target="_blank" >RIV/00064203:_____/13:10209713 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/13:10209713

Result on the web

<a href="http://dx.doi.org/10.1007/s12253-013-9633-1" target="_blank" >http://dx.doi.org/10.1007/s12253-013-9633-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12253-013-9633-1" target="_blank" >10.1007/s12253-013-9633-1</a>

Result language

angličtina

Original language name

p16(INK4a) Immunoprofiles of Squamous Lesions of the Uterine Cervix-Implications for the Reclassification of Atypical Immature Squamous Metaplasia

Original language description

p16(INK4a) immunoprofiles of non-precancerous and dysplastic squamous cervical lesions were defined and applied to the reclassification of atypical immature squamous metaplasia (AIM). The immunoexpression of cytokeratin 17 (CK 17) in AIM was also evaluated. Totally, 295 cervical cone biopsies representing squamous metaplasia, reactive changes, koilocytosis, flat condyloma, CIN I, CIN II, CIN III and AIM were subjected to p16(INK4a) immunohistochemistry. AIM cases were analyzed using CK 17 antibody. Typical p16(INK4a) immunoprofiles for the metaplastic, LSIL/HPV and HSIL phenotypes were recorded and used for the categorization of AIM into particular phenotype groups. Results were correlated with CK 17 immunoexpression. All CIN II and CIN III lesions, all but one case of CIN I and all flat condylomas overexpressed p16(INK4a). Other non-precancerous lesions, including koilocytosis, were predominantly negative. Contrary to the sporadic and focal immunostaining, diffuse positivity was assoc

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pathology Oncology Research

ISSN

1219-4956

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

4

Country of publishing house

HU - HUNGARY

Number of pages

8

Pages from-to

707-714

UT code for WoS article

000324638600012

EID of the result in the Scopus database

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