Treatment Options for Children with Monogenic Forms of Obesity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F13%3A10209826" target="_blank" >RIV/00064203:_____/13:10209826 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/13:10209826 RIV/00023761:_____/13:#0000387 RIV/00216208:11120/13:43907257
Result on the web
<a href="http://www.karger.com/Article/FullText/342556" target="_blank" >http://www.karger.com/Article/FullText/342556</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Treatment Options for Children with Monogenic Forms of Obesity
Original language description
Mutations in genes involved in energy balance regulation within the central nervous system lead to monogenic forms of obesities. Individuals with these mutations are characterized by early-onset obesity and in some cases by endocrine abnormalities. Carriers of leptin gene mutations are able to normalize their body weight after daily subcutaneous leptin administration. Pharmacotherapy targeting the specific-gene deficiencies has not clinically been tested in other monogenic obesities. Mutations in the melanocortin 4 receptor gene (MC4R) represent the most common monogenic cause of human obesity. Several treatment options have been investigated in subjects with MC4R mutations. Few studies showed that an intensive life-style intervention induces similar weight reduction in MC4R mutation carriers in comparison to MC4R mutation noncarriers. However, long-term body weight maintenance is hardly ever achieved in MC4R mutation carriers. Sibutramine, serotonin and noradrenalin reuptake inhibitor
Czech name
—
Czech description
—
Classification
Type
D - Article in proceedings
CEP classification
FG - Paediatrics
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/NT12342" target="_blank" >NT12342: Nutrition, obesity and metabolic syndrome in children and adolescents - influence on lipid metabolism and adipokines, changes after weight reduction</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
World review of nutrition and dietetics
ISBN
978-3-318-02265-0
ISSN
0084-2230
e-ISSN
—
Number of pages
8
Pages from-to
105-112
Publisher name
KARGER
Place of publication
BASEL
Event location
Paris
Event date
Mar 1, 2012
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000316645700016