Melanocortin pathways: suppressed and stimulated melanocortin-4 receptor (MC4R)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43920727" target="_blank" >RIV/00216208:11120/20:43920727 - isvavai.cz</a>
Alternative codes found
RIV/00023761:_____/20:N0000026
Result on the web
<a href="https://doi.org/10.33549/physiolres.934512" target="_blank" >https://doi.org/10.33549/physiolres.934512</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934512" target="_blank" >10.33549/physiolres.934512</a>
Alternative languages
Result language
angličtina
Original language name
Melanocortin pathways: suppressed and stimulated melanocortin-4 receptor (MC4R)
Original language description
Leptin-melanocortin pathway plays an essential role in the body weight regulation. Enhanced melanocortin signaling in the hypothalamus results in both decreased food intake and increased energy expenditure. The discovery of monogenic obesities with dysfunction of melanocortin-4 receptor (MC4R) greatly contributed to understanding of energy balance regulation. This review presents phenotypical characterization and prevalence of the MC4R gene mutations. Genome-wide association studies revealed that MC4R gene is significantly related not only to monogenic obesities but also to common obesity. An interaction of variants in the MC4R gene with fat mass and obesity associated (FTO) gene significantly increases the risk for obesity, particularly in adolescence. On the other hand, about 15 % of the MC4R gene variants result in a gain of function that protects against obesity and is associated with favorable metabolic profile. Long-term attempts to activate the MC4R have recently been finalized by a discovery of setmelanotide, a novel specific MC4R agonist that is devoid of untoward cardiovascular side-effects. The employment of specific MC4R agonists may open new horizons not only in the treatment of rare monogenic obesities but also in some common obesities where stimulation of MC4R could be achieved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
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Volume of the periodical
69
Issue of the periodical within the volume
Suppl. 2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
10
Pages from-to
"S245"-"S254"
UT code for WoS article
000581646000009
EID of the result in the Scopus database
2-s2.0-85094570401