Th1 and Th17 but no Th2-related cytokine spectrum in the cerebrospinal fluid of children with Borrelia-related facial nerve palsy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F13%3A10210500" target="_blank" >RIV/00064203:_____/13:10210500 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/13:10210500
Result on the web
<a href="http://www.fluidsbarrierscns.com/content/10/1/30" target="_blank" >http://www.fluidsbarrierscns.com/content/10/1/30</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/2045-8118-10-30" target="_blank" >10.1186/2045-8118-10-30</a>
Alternative languages
Result language
angličtina
Original language name
Th1 and Th17 but no Th2-related cytokine spectrum in the cerebrospinal fluid of children with Borrelia-related facial nerve palsy
Original language description
BACKGROUND: Chemokines and cytokines in cerebrospinal fluid (CSF) and serum have been extensively studied in adults with neuroborreliosis (NB), whereas there are limited data about the pediatric population. In adults, T helper type 1 (Th1) and Th17-related cytokines were observed during acute NB. In children, the Th2 response is thought to moderate the disease course. The aim of this study was to determine the chemokine-cytokine profile in children with acute NB displaying Borrelia-related peripheral facial nerve palsy (PFNP). METHODS: Luminex multiple bead technology was used for the detection of twelve cytokines and chemokines in the CSF and serum of three groups: 1) children with Borrelia-related PFNP (BPFNP); 2) children with non-borrelial "idiopathic" PFNP (NIPFNP); and 3) age-related controls. RESULTS: In BPFNP, cytokines-chemokines related to a non-specific pro-inflammatory activity and specific Th1/Th17 responses were detected in CSF, and elevated IL-7 and IL-10 levels were obs
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Fluids and Barriers of the CNS
ISSN
2045-8118
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
30
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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