IL-12 inhibits the TGF-beta-dependent T cell developmental programs and skews the TGF-beta-induced differentiation into a Th1-like direction

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00371356" target="_blank" >RIV/68378050:_____/12:00371356 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/12:10104201
Result on the web
<a href="http://dx.doi.org/10.1016/j.imbio.2011.07.032" target="_blank" >http://dx.doi.org/10.1016/j.imbio.2011.07.032</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.imbio.2011.07.032" target="_blank" >10.1016/j.imbio.2011.07.032</a>

Result language
angličtina
Original language name
IL-12 inhibits the TGF-beta-dependent T cell developmental programs and skews the TGF-beta-induced differentiation into a Th1-like direction
Original language description
Development and differentiation of Th cells is highly plastic and strictly regulated by cytokines. We show negative regulation of TGF-beta-dependent differentiation programs by IL-12. Development of TGF-b-induced regulatory T cells (iTregs) or TGF-b/IL-6-activated Th17 cells from purified mouse CD4+CD25- T cells stimulated with anti-CD3 was abrogated by IL-12, establishing different developmental program. IL-12 inhibited expression of lineage-specific transcription factors Foxp3 and RORgt in developingTregs and Th17 cells. IL-12 altered development of iTregs and Th17 cells even added after 48 h. Cells activated by TGF-b and IL-12 had increased expression of T-bet, produced Th1 cytokines IFN-g and IL-2 and expressed IL-18 receptor and C-C chemokine receptor type 5. Cells activated by both TGF-b and IL-12 stimulated macrophages to produce nitric oxide. IL-12 is shown as superior cytokine able to skew ongoing TGF-b-dependent iTreg or Th17 developmental program to Th1-like direction.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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