Interleukin-10 production by B cells is regulated by cytokines, but independently of GATA-3 or FoxP3 expression

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00539321" target="_blank" >RIV/68378041:_____/20:00539321 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/20:10404020
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S0008874919301893?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0008874919301893?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cellimm.2019.103987" target="_blank" >10.1016/j.cellimm.2019.103987</a>

Result language
angličtina
Original language name
Interleukin-10 production by B cells is regulated by cytokines, but independently of GATA-3 or FoxP3 expression
Original language description
The knowledge of mechanisms of regulation of IL-10 production by B cells remains still very limited. We show here that highly purified mouse B cells stimulated with LPS produce significant levels of IL-10, but Bregs in our model do not express detectable level of either Foxp3 or GATA-3. Nevertheless, IL-10 production by B cells is regulated by cytokines. In activated B cells, IL-10 production was significantly enhanced by IFN-gamma and decreased in the presence of IL-4 or TGF-beta. These findings are in sharp contrast with the observations in T cells, where IL-10 production correlates with GATA-3 or FoxP3 expression, and the cytokines regulate IL-10 production in a reverse manner than in activated B cells. These results thus show that the production of IL-10 by Bregs is regulated by cytokines independently of the expression of GATA-3 and FoxP3, which is clearly different from GATA-3-dependent IL-10 production by activated Th2 cells and FoxP3 expression in IL-10-producing Tregs.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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