Distinct regulatory roles of transforming growth factor-beta and interleukin-4 in the development and maintenance of natural and induced CD4+ CD25+ Foxp3+ regulatory T cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F09%3A00333972" target="_blank" >RIV/68378050:_____/09:00333972 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Distinct regulatory roles of transforming growth factor-beta and interleukin-4 in the development and maintenance of natural and induced CD4+ CD25+ Foxp3+ regulatory T cells

Original language description

The development and function of CD4+CD25+Foxp3+ regulatory T cells (Tregs) are strictly regulated by cytokines. Here we show that TGF-b and IL-4 play a crucial and antagonistic role in the development of Tregs and have distinct effects on maintenance ofnatural (nTregs) and antigen-induced (iTregs) Tregs. We demonstrated that CD4+CD25+Foxp3+ iTregs develop upon alloantigenic stimulation in the presence of TGF-b exclusively from CD4+CD25-Foxp3- precursors. Both induction of Foxp3 expression and Treg proliferation were prevented when the cells were stimulated in the presence of IL-4. IL-4 decreased the number of Foxp3+ cells in a population of iTregs while it substantially supported the survival of nTregs. iTregs inhibit cell proliferation comparably tonTregs and their suppressive capacity is not modulated by IL-4. These data suggest that TGF-b and IL-4 differentially regulate the development and maintenance of Tregs but have no influence on the suppressive activity of Tregs.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Immunology

ISSN

0019-2805

e-ISSN

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Volume of the periodical

128

Issue of the periodical within the volume

1 Suppl

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

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UT code for WoS article

000268703800052

EID of the result in the Scopus database

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