Distinct regulatory roles of transforming growth factor-? and interleukin-4 in the development and maintenance of natural and induced CD4+ CD25+ Foxp3+ regulatory T cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F09%3A10000410" target="_blank" >RIV/00216208:11310/09:10000410 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Distinct regulatory roles of transforming growth factor-? and interleukin-4 in the development and maintenance of natural and induced CD4+ CD25+ Foxp3+ regulatory T cells
Original language description
The development and function of CD4+ CD25+ Foxp3+ regulatory T cells are strictly regulated by cytokines. Here we show that transforming growth factor-? and interleukin-4 play a crucial and antagonistic role in the development of Tregs, distinctly sustain Foxp3 expression and the number of Tregs, but have no influence on the suppressive activity of Tregs on a per-cell basis.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Immunology
ISSN
0019-2805
e-ISSN
—
Volume of the periodical
128
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
—
UT code for WoS article
000268703800052
EID of the result in the Scopus database
—