The Role of Mouse Mesenchymal Stem Cells in Differentiation of Naive T-Cells into Anti-Inflammatory Regulatory T-Cell or Proinflammatory Helper T-Cell 17 Population
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10104237" target="_blank" >RIV/00216208:11310/12:10104237 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/12:00375938
Result on the web
<a href="http://dx.doi.org/10.1089/scd.2011.0157" target="_blank" >http://dx.doi.org/10.1089/scd.2011.0157</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1089/scd.2011.0157" target="_blank" >10.1089/scd.2011.0157</a>
Alternative languages
Result language
angličtina
Original language name
The Role of Mouse Mesenchymal Stem Cells in Differentiation of Naive T-Cells into Anti-Inflammatory Regulatory T-Cell or Proinflammatory Helper T-Cell 17 Population
Original language description
Bone marrow-derived mesenchymal stem cells (MSCs) can produce significant levels of transforming growth factor beta and interleukin-6. These two cytokines represent the key factors that reciprocally regulate the development of naive T-cells into regulatory T-cell (Treg) population or proinflammatory T helper 17 (Th17) cells. We demonstrated that MSCs and their products effectively regulate expression of transcription factors Foxp3 and RORgammat and control the development of Tregs and Th17 cells in a population of alloantigen-activated mouse spleen cells. The immunomodulatory effects of MSCs were more pronounced when these cells were stimulated by addition of anti-inflammatory or proinflammatory cytokines. The results showed that MSCs represent important players that reciprocally regulate the differentiation of naive T-cells into anti-inflammatory Tregs or proinflammatory Th17 cell population and thereby can modulate immunopathological or transplantation reactions.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Stem Cells and Development
ISSN
1547-3287
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
901-910
UT code for WoS article
000302222700008
EID of the result in the Scopus database
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