Mesenchymal Stem Cells Attenuate the Adverse Effects of Immunosuppressive Drugs on Distinct T Cell Subopulations
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00476434" target="_blank" >RIV/68378041:_____/17:00476434 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/17:10366569
Result on the web
<a href="http://dx.doi.org/10.1007/s12015-016-9703-3" target="_blank" >http://dx.doi.org/10.1007/s12015-016-9703-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12015-016-9703-3" target="_blank" >10.1007/s12015-016-9703-3</a>
Alternative languages
Result language
angličtina
Original language name
Mesenchymal Stem Cells Attenuate the Adverse Effects of Immunosuppressive Drugs on Distinct T Cell Subopulations
Original language description
Immunosuppressive drugs are widely used to treat undesirable immune reaction, however their clinical use is often limited by harmful side effects. The combined application of immunosuppressive agents with mesenchymal stem cells (MSCs) offers a promising alternative approach that enables the reduction of immunosuppressive agent doses and simultaneously maintains or improves the outcome of therapy. The present study aimed to determinate the effects of immunosuppressants on individual T cell subpopulations and to investigate the efficacy of MSC-based treatment combined with immunosuppressive drugs. We tested the effect of five widely used immunosuppressants with different action mechanisms: cyclosporine A, mycophenolate mofetil, rapamycin, and two glucocorticoids -prednisone and dexamethasone in combination with MSCs on mouse CD4(+) and CD8(+) lymphocyte viability and activation, Th17 (ROR gamma t(+)), Th1 (T-bet(+)), Th2 (GATA-3(+)) and Treg (Foxp3(+)) cell proportion and on the production of corresponding key cytokines (IL-17, IFN gamma,IL-4 and IL-10). We showed that MSCs modulate the actions of immunosuppressants and in combination with immunosuppressive drugs display distinct effect on cell activation and balance among different T lymphocytes subpopulations and exert a suppressive effect on proinflammatory T cell subsets while promoting the functions of anti-inflammatory Treg lymphocytes. The results indicated that MSC-based therapy could be a powerful strategy to attenuate the negative effects of immunosuppressive drugs on the immune system.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Stem Cell Reviews and Reports
ISSN
1550-8943
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
104-115
UT code for WoS article
000397212100015
EID of the result in the Scopus database
2-s2.0-84995810953