Study of Synergistic Effect of Mesenchymal Stem Cells and Immunosuppressive Drugs on an Inflammatory Response in an In Vitro Model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00491806" target="_blank" >RIV/68378041:_____/17:00491806 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Study of Synergistic Effect of Mesenchymal Stem Cells and Immunosuppressive Drugs on an Inflammatory Response in an In Vitro Model

Original language description

Mesenchymal stem cells (MSCs) in combination with immunosuppressive drugs are beneficial in the treatment of inflammatory diseases or transplantation reaction. We tested immunosuppressive drugs with different mechanism of action: cyclosporine A, mycophenolate mofetil and rapamycin in combination with MSCs. By flow cytometry we determined T regulatory cells (CD4+Foxp3+) and Th 17 cells (CD4+RORt+) proportion and the production of IL-17 was measured by ELISA. This study demonstrated that MSCs in combination with different immunosuppressive agents at low concentration have distinct effect on the Treg/Th17 balance.

Czech name

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Czech description

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Type

C - Chapter in a specialist book

CEP classification

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OECD FORD branch

10601 - Cell biology

Project

<a href="/en/project/LO1309" target="_blank" >LO1309: Cell Therapy and Tissue Repair</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name

Nanomaterials in Biomedical research

ISBN

978-80-906655-5-2

Number of pages of the result

5

Pages from-to

124-128

Number of pages of the book

140

Publisher name

Proxima Tisk, s.r.o.

Place of publication

Praha 3

UT code for WoS chapter

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