Factors associated with FEV1 decline in cystic fibrosis: analysis of the ECFS Patient Registry

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10292759" target="_blank" >RIV/00064203:_____/14:10292759 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/14:10292759

Result on the web

<a href="http://dx.doi.org/10.1183/09031936.00166412" target="_blank" >http://dx.doi.org/10.1183/09031936.00166412</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1183/09031936.00166412" target="_blank" >10.1183/09031936.00166412</a>

Result language

angličtina

Original language name

Factors associated with FEV1 decline in cystic fibrosis: analysis of the ECFS Patient Registry

Original language description

Pulmonary insufficiency is the main cause of death in cystic fibrosis (CF). We analysed forced expiratory volume in 1 s (FEV1) data of 14 732 patients registered in the European Cystic Fibrosis Society Patient Registry (ECFSPR) database in 2007. We usedlinear and logistic regressions to investigate associations between FEV1 % predicted and clinical outcomes. Body mass index (BMI), chronic infection by Pseudomonas aeruginosa, pancreatic status and CF-related diabetes (CFRD) showed a statistically significant (all p<0.0001) and clinically relevant effect on FEV1 % pred after adjusting for age. Patients with a lower BMI experience a six-fold increased odds ratio (95% CI 5.0-7.3) of having severe lung disease (FEV1 <40% pred) compared to patients with normal BMI. Being chronically infected with P. aeruginosa increases the odds ratio of severe lung disease by 2.4 (95% CI 2.0-2.7), and patients with pancreatic insufficiency experience a 2.0-fold increased odds ratio (95% CI 1.6-2.5) of seve

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FC - Pneumology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Respiratory Journal

ISSN

0903-1936

e-ISSN

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Volume of the periodical

43

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

125-133

UT code for WoS article

000329552200018

EID of the result in the Scopus database

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