Cystic fibrosis related diabetes in Europe: Prevalence, risk factors and outcome; Olesen et al
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10412360" target="_blank" >RIV/00216208:11130/20:10412360 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/20:10412360
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JVNy_iJkB8" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JVNy_iJkB8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jcf.2019.10.009" target="_blank" >10.1016/j.jcf.2019.10.009</a>
Alternative languages
Result language
angličtina
Original language name
Cystic fibrosis related diabetes in Europe: Prevalence, risk factors and outcome; Olesen et al
Original language description
Background: Cystic fibrosis related diabetes (CFRD) has implications for morbidity and mortality with several risk factors identified. We studied the epidemiology of CFRD in the large dataset of the European Cystic Fibrosis Society Patient registry. Methods: Data on CF patients were investigated for the prevalence of CFRD as well as for any association with suggested risk factors and effects. Results: CFRD increased by approximately ten percentage points every decade from ten years of age. Prevalence was higher in females in the younger age groups. CFRD was associated with severe CF genotypes (OR = 3.11, 95%CI: 2.77-3.48), pancreatic insufficiency (OR = 1.46, 95%CI: 1.39-1.53) and female gender (OR = 1.28, 95%CI: 1.21-1.34). Patients with CFRD had higher odds of being chronically infected with Pseudomonas aeruginosa, Burkholderia cepacia complex and Stenotrophomonas maltophilia than patients without CFRD, higher odds of having FEV1% of predicted <40% (OR = 1.82, 95%CI: 1.70-1.94) and higher odds of having BMI SDS <=-2 than patients without CFRD (OR = 1.24, 95%CI: 1.15-1.34). Conclusions: Severe genotype, pancreatic insufficiency and female gender remain considerable intrinsic risk factors for early acquisition of CFRD. CFRD is associated with infections, lower lung function and poor nutritional status. Early diagnosis and aggressive treatment of CFRD are more important than ever with increasing life span. (C) 2019 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30203 - Respiratory systems
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cystic Fibrosis
ISSN
1569-1993
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
321-327
UT code for WoS article
000542305900027
EID of the result in the Scopus database
2-s2.0-85074475996