Helios Expression in T-regulatory Cells in Patients with di George Syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10292990" target="_blank" >RIV/00064203:_____/14:10292990 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/14:10292990
Result on the web
<a href="http://dx.doi.org/10.1007/s10875-014-0071-y" target="_blank" >http://dx.doi.org/10.1007/s10875-014-0071-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10875-014-0071-y" target="_blank" >10.1007/s10875-014-0071-y</a>
Alternative languages
Result language
angličtina
Original language name
Helios Expression in T-regulatory Cells in Patients with di George Syndrome
Original language description
Syndrome diGeorge is associated amongst other clinical signs with various degrees of thymic dysplasia, related immunodeficiency and autoimmune disorders. Helios, a transcription factor from Ikaros family, has been proposed as a marker for thymus derivedTregs. We therefore examined Helios + Tregs in a cohort of patients with genetically proven diGeorge syndrome with typical T cell lymphopenia due to the thymic pathology. T cells, FoxP3+ Tregs and Helios + FoxP3+ Tregs were examined in 52 samples from 37patients. One patient with diGeorge/CHARGE syndrome with total thymic aplasia was also included. Statistical analysis was performed using a linear regression comparison. Total absolute Tregs were significantly lower in diGeorge patients as compared to controls in all age groups (0-20 years) (p = 0.0016). The difference was more expressed in the first four years of age. Relative Treg numbers expressed as the percentage of Tregs in CD4+ T-cells, however, were not different in patients and
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT13287" target="_blank" >NT13287: The regulation of immunity in syndrome diGeorge</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Clinical Immunology
ISSN
0271-9142
e-ISSN
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Volume of the periodical
34
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
864-870
UT code for WoS article
000342212000016
EID of the result in the Scopus database
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