Kinetics of Helios(+) and Helios(-) T regulatory cell subsets in the circulation of healthy pregnant women

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00508512" target="_blank" >RIV/68378041:_____/19:00508512 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10394877 RIV/00216208:11310/19:10394877 RIV/00064165:_____/19:10394877

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/sji.12754" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1111/sji.12754</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/sji.12754" target="_blank" >10.1111/sji.12754</a>

Result language

angličtina

Original language name

Kinetics of Helios(+) and Helios(-) T regulatory cell subsets in the circulation of healthy pregnant women

Original language description

Regulatory T cells (Tregs) play a critical role in the maintenance of a pregnancy. While the kinetics of the number of peripheral blood Tregs has been satisfactorily described in mouse models, analysis of these cell populations in human pregnancy is complicated by high variability in the quantity of Tregs and inconsistencies in the markers used for detecting different types of Treg. In the light of this, we set out to investigate the kinetics of various types of Treg, including CD45RA, GARP and PD-1(+) Tregs, in the peripheral blood of pregnant women in the first, second and third trimester, and at the time of delivery. Tregs, defined as a CD4(+)CD25(++)CD127(dim)Foxp3(+) population of leucocytes, were detected using flow cytometry. Natural thymus-derived Tregs and induced Tregs in the peripheral blood were distinguished by the expression or absence of a Helios marker, respectively. Our results showed that during normal pregnancy the sizes of various Treg subpopulations varied across women and also in an individual woman did not remain constant but varied significantly, most notable being the decrease observed at the time of delivery. Helios(-) cells were significantly less frequent in the peripheral blood of healthy pregnant women than Helios(+) cells, and the majority of Tregs were Helios(+)PD-1(+) Tregs.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scandinavian Journal of Immunology

ISSN

0300-9475

e-ISSN

—

Volume of the periodical

89

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

UNSP e12754

UT code for WoS article

000461888800006

EID of the result in the Scopus database

2-s2.0-85062615986