miR-9 is a tumor suppressor in pediatric AML with t(8;21)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10293010" target="_blank" >RIV/00064203:_____/14:10293010 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/14:10293010

Result on the web

<a href="http://dx.doi.org/10.1038/leu.2013.357" target="_blank" >http://dx.doi.org/10.1038/leu.2013.357</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/leu.2013.357" target="_blank" >10.1038/leu.2013.357</a>

Result language

angličtina

Original language name

miR-9 is a tumor suppressor in pediatric AML with t(8;21)

Original language description

MicroRNAs (miRNAs) play a pivotal role in the regulation of hematopoiesis and development of leukemia. Great interest emerged in modulating miRNA expression for therapeutic purposes. In order to identify miRNAs, which specifically suppress leukemic growth of acute myeloid leukemia (AML) with t(8; 21), inv(16) or mixed lineage leukemia (MLL) rearrangement by inducing differentiation, we conducted a miRNA expression profiling in a cohort of 90 cytogenetically characterized, de novo pediatric AML cases. Four miRNAs, specifically downregulated in MLL-rearranged, t(8; 21) or inv(16) AMLs, were characterized by their tumor-suppressive properties in cell lines representing those respective cytogenetic groups. Among those, forced expression of miR-9 reduced leukemic growth and induced monocytic differentiation of t(8; 21) AML cell lines in vitro and in vivo. The tumor-suppressive functions of miR-9 were specifically restricted to AML cell lines and primary leukemic blasts with t(8; 21). On the

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Leukemia

ISSN

0887-6924

e-ISSN

—

Volume of the periodical

28

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

1022-1032

UT code for WoS article

000336661500006

EID of the result in the Scopus database

—