MicroRNA-106b similar to 25 cluster is upregulated in relapsed MLL-rearranged pediatric acute myeloid leukemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10332525" target="_blank" >RIV/00064203:_____/16:10332525 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/16:10332525

Result on the web

<a href="http://dx.doi.org/10.18632/oncotarget.10270" target="_blank" >http://dx.doi.org/10.18632/oncotarget.10270</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.18632/oncotarget.10270" target="_blank" >10.18632/oncotarget.10270</a>

Result language

angličtina

Original language name

MicroRNA-106b similar to 25 cluster is upregulated in relapsed MLL-rearranged pediatric acute myeloid leukemia

Original language description

The most important reason for therapy failure in pediatric acute myeloid leukemia (AML) is relapse. In order to identify miRNAs that contribute to the clonal evolution towards relapse in pediatric AML, miRNA expression profiling of 127 de novo pediatric AML cases were used. In the diagnostic phase, no miRNA signatures could be identified that were predictive for relapse occurrence, in a large pediatric cohort, nor in a nested mixed lineage leukemia (MLL)-rearranged pediatric cohort. AML with MLL- rearrangements are found in 15-20% of all pediatric AML samples, and reveal a relapse rate up to 50% for certain translocation partner subgroups. Therefore, microRNA expression profiling of six paired initial diagnosis-relapse MLL-rearranged pediatric AML samples (test cohort) and additional eight paired initial diagnosis-relapse samples with MLL-rearrangements (validation cohort) was performed. A list of 53 differentially expressed miRNAs was identified of which the miR-106b similar to 25 cluster, located in intron 13 of MCM7, was the most prominent. These differentially expressed miRNAs however could not predict a relapse in de novo AML samples with MLL-rearrangements at diagnosis. Furthermore, higher mRNA expression of both MCM7 and its upstream regulator E2F1 was found in relapse samples with MLL-rearrangements. In conclusion, we identified the miR-106b similar to 25 cluster to be upregulated in relapse pediatric AML with MLL-rearrangements.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncotarget

ISSN

1949-2553

e-ISSN

—

Volume of the periodical

7

Issue of the periodical within the volume

30

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

48412-48422

UT code for WoS article

000385413000123

EID of the result in the Scopus database

2-s2.0-84982802784