miR expression profiling at diagnosis predicts relapse in pediatric precursor B-cell acute lymphoblastic leukemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F16%3A10323722" target="_blank" >RIV/00216208:11130/16:10323722 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/16:10323722
Result on the web
<a href="http://dx.doi.org/10.1002/gcc.22334" target="_blank" >http://dx.doi.org/10.1002/gcc.22334</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/gcc.22334" target="_blank" >10.1002/gcc.22334</a>
Alternative languages
Result language
angličtina
Original language name
miR expression profiling at diagnosis predicts relapse in pediatric precursor B-cell acute lymphoblastic leukemia
Original language description
Our aim was to identify miRNAs that can predict risk of relapse in pediatric patients with acute lymphoblastic leukemia (ALL). Following high-throughput miRNA expression analysis (48 samples), five miRs were selected for further confirmation performed by real time quantitative PCR on a cohort of precursor B-cell ALL patients (n=138). The results were correlated with clinical parameters and outcome. Low expression of miR-151-5p, and miR-451, and high expression of miR-1290 or a combination of all three predicted inferior relapse free survival (P=0.007, 0.042, 0.025, and <0.0001, respectively). Cox regression analysis identified aberrant expression of the three miRs as an independent prognostic marker with a 10.5-fold increased risk of relapse (P=0.041) in PCR-MRD non-high risk patients. Furthermore, following exclusion of patients harboring IKZF1 deletion, the aberrant expression of all three miRs could identify patients with a 24.5-fold increased risk to relapse (P<0.0001). The prognostic relevance of the three miRNAs was evaluated in a non-BFM treated precursor B-cell ALL cohort (n=33). A significant correlation between an aberrant expression of at least one of the three miRs and poor outcome was maintained (P<0.0001). Our results identify an expression profile of miR-151-5p, miR-451, and miR-1290 as a novel biomarker for outcome in pediatric precursor B-cell ALL patients, regardless of treatment protocol. The use of these markers may lead to improved risk stratification at diagnosis and allow early therapeutic interventions in an attempt to improve survival of high risk patients. (c) 2015 Wiley Periodicals, Inc.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP304%2F12%2F2214" target="_blank" >GAP304/12/2214: Transcription regulation of the HOX genes in normal and leukemic hematopoiesis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Genes Chromosomes and Cancer
ISSN
1045-2257
e-ISSN
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Volume of the periodical
55
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
328-339
UT code for WoS article
000370168100004
EID of the result in the Scopus database
2-s2.0-84958751149