Biological insights from 108 schizophrenia-associated genetic loci

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10293016" target="_blank" >RIV/00064203:_____/14:10293016 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/14:10293016

Result on the web

<a href="http://dx.doi.org/10.1038/nature13595" target="_blank" >http://dx.doi.org/10.1038/nature13595</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/nature13595" target="_blank" >10.1038/nature13595</a>

Result language

angličtina

Original language name

Biological insights from 108 schizophrenia-associated genetic loci

Original language description

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature

ISSN

0028-0836

e-ISSN

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Volume of the periodical

511

Issue of the periodical within the volume

7510

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

421-427

UT code for WoS article

000339335700037

EID of the result in the Scopus database

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