Schizophrenia risk from complex variation of complement component 4
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10337226" target="_blank" >RIV/00064203:_____/16:10337226 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/16:10337226
Result on the web
<a href="http://dx.doi.org/10.1038/nature16549" target="_blank" >http://dx.doi.org/10.1038/nature16549</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/nature16549" target="_blank" >10.1038/nature16549</a>
Alternative languages
Result language
angličtina
Original language name
Schizophrenia risk from complex variation of complement component 4
Original language description
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms. Schizophrenia's strongest genetic association at a population level involves variation in the major histocompatibility complex (MHC) locus, but the genes and molecular mechanisms accounting for this have been challenging to identify. Here we show that this association arises in part from many structurally diverse alleles of the complement component 4 (C4) genes. We found that these alleles generated widely varying levels of C4A and C4B expression in the brain, with each common C4 allele associating with schizophrenia in proportion to its tendency to generate greater expression of C4A. Human C4 protein localized to neuronal synapses, dendrites, axons, and cell bodies. In mice, C4 mediated synapse elimination during postnatal development. These results implicate excessive complement activity in the development of schizophrenia and may help explain the reduced numbers of synapses in the brains of individuals with schizophrenia.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature
ISSN
0028-0836
e-ISSN
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Volume of the periodical
530
Issue of the periodical within the volume
7589
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
177-183
UT code for WoS article
000369916700030
EID of the result in the Scopus database
2-s2.0-84958074030