APOE and Spatial Navigation in Amnestic MCI: Results From a Computer-Based Test
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10293020" target="_blank" >RIV/00064203:_____/14:10293020 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/14:00437833 RIV/00216208:11130/14:10293020 RIV/00159816:_____/14:00061069
Result on the web
<a href="http://dx.doi.org/10.1037/neu0000072" target="_blank" >http://dx.doi.org/10.1037/neu0000072</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1037/neu0000072" target="_blank" >10.1037/neu0000072</a>
Alternative languages
Result language
angličtina
Original language name
APOE and Spatial Navigation in Amnestic MCI: Results From a Computer-Based Test
Original language description
Objective: We investigated the association between APOE epsilon 4 status and spatial navigation in patients with amnestic mild cognitive impairment (aMCI) and assessed the role of hippocampal volume in this association. Method: Participants were 74 patients with clinically confirmed aMCI (33 APOE epsilon 4 noncarriers, 26 heterozygous, and 15 homozygous epsilon 4 carriers). Body-centered (egocentric) and world-centered (allocentric) spatial navigation in a computerized human analogue of the Morris WaterMaze was assessed. Brain MRI with subsequent automated hippocampal volumetry was included. Results: Groups were similar in neuropsychological profile. Controlling for age, sex, education, and free memory recall, the APOE epsilon 4 carriers performed more poorly on all spatial navigation subtasks (ps < .05). APOE epsilon 4 homozygotes performed worse than heterozygotes (p = .021). Right hippocampal volume accounted for the differences in allocentric and delayed subtasks (ps > .05), but n
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuropsychology
ISSN
0894-4105
e-ISSN
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Volume of the periodical
28
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
676-684
UT code for WoS article
000341291800002
EID of the result in the Scopus database
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