The Combined Effect of APOE and BDNF Va166Met Polymorphisms on Spatial Navigation in Older Adults

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00073526" target="_blank" >RIV/00159816:_____/20:00073526 - isvavai.cz</a>

Alternative codes found

RIV/00023884:_____/20:00008778

Result on the web

<a href="https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200615" target="_blank" >https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200615</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3233/JAD-200615" target="_blank" >10.3233/JAD-200615</a>

Result language

angličtina

Original language name

The Combined Effect of APOE and BDNF Va166Met Polymorphisms on Spatial Navigation in Older Adults

Original language description

Background: The apolipoprotein E (APOE) epsilon 4 allele is associated with episodic memory and spatial navigation deficits. The brain-derived neurotrophic factor (BDNF) Met allele may further worsen memory impairment in APOE epsilon 4 carriers but its role in APOE epsilon 4-related spatial navigation deficits has not been established. Objective: We examined influence of APOE and BDNF Va166Met polymorphism combination on spatial navigation and volumes of selected navigation-related brain regions in cognitively unimpaired (CU) older adults and those with amnestic mild cognitive impairment (aMCI). Methods: 187 participants (aMCI [n = 116] and CU [n=71]) from the Czech Brain Aging Study were stratified based on APOE and BDNF Va166Met polymorphisms into four groups: epsilon 4(-)/BDNFval/val, epsilon 4(-)/BDNFMet, epsilon 4(+)/BDNFval/val, and epsilon 4(+)/BDNFMet The participants underwent comprehensive neuropsychological examination, brain MRI, and spatial navigation testing of egocentric, allocentric, and allocentric delayed navigation in a real-space human analogue of the Morris water maze. Results: Among the aMCI participants, the epsilon 4(+)/BDNFMet group had the least accurate egocentric navigation performance (p &lt; 0.05) and lower verbal memory performance than the epsilon 4(-)/BDNFval/val group (p = 0.007). The epsilon 4(+)/BDNFMet group had smaller hippocampal and entorhinal cortical volumes than the epsilon 4(-)/BDNFval/val (p &lt;= 0.019) and epsilon 4(-)/BDNFMet (p &lt;= 0.020) groups. Among the CU participants, the epsilon 4(+)/BDNFMet group had less accurate allocentric and allocentric delayed navigation performance than the epsilon 4(-)/BDNFval/val group (p &lt; 0.05). Conclusion: The combination of APOE epsilon 4 and BDNF Met polymorphisms is associated with more pronounced egocentric navigation impairment and atrophy of the medial temporal lobe regions in individuals with aMCI and less accurate allocentric navigation in CU older adults.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Alzheimers Disease

ISSN

1387-2877

e-ISSN

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Volume of the periodical

78

Issue of the periodical within the volume

4

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

20

Pages from-to

1473-1492

UT code for WoS article

000596593800016

EID of the result in the Scopus database

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