Spatial navigation deficits in early Alzheimer's disease: the role of biomarkers and APOE genotype

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F25%3A00010216" target="_blank" >RIV/00023884:_____/25:00010216 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/25:10498658 RIV/00216208:11210/25:10498658 RIV/00216208:11130/25:10498658

Result on the web

<a href="https://link.springer.com/article/10.1007/s00415-025-13151-8" target="_blank" >https://link.springer.com/article/10.1007/s00415-025-13151-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00415-025-13151-8" target="_blank" >10.1007/s00415-025-13151-8</a>

Result language

angličtina

Original language name

Spatial navigation deficits in early Alzheimer's disease: the role of biomarkers and APOE genotype

Original language description

Spatial navigation deficits are early symptoms of Alzheimer's disease (AD). The apolipoprotein E (APOE) epsilon 4 allele is the most important genetic risk factor for AD. This study investigated effects of APOE genotype on spatial navigation in biomarker-defined individuals with amnestic mild cognitive impairment (aMCI) and associations of AD biomarkers and atrophy of AD-related brain regions with spatial navigation.Methods107 participants, cognitively normal older adults (CN, n = 48) and aMCI individuals stratified into AD aMCI (n = 28) and non-AD aMCI (n = 31) groups, underwent cognitive assessment, brain MRI, and spatial navigation assessment using the Virtual Supermarket Test with egocentric and allocentric tasks and a self-report questionnaire. Cerebrospinal fluid (CSF) biomarkers (amyloid-beta 1-42, phosphorylated tau181 and total tau) and amyloid PET imaging were assessed in aMCI participants.ResultsAD aMCI participants had the highest prevalence of APOE epsilon 4 carriers and worst allocentric navigation. CSF levels of AD biomarkers and atrophy in AD-related brain regions were associated with worse allocentric navigation. Between-group differences in spatial navigation and associations with AD biomarkers and regional brain atrophy were not influenced by APOE genotype. Self-reported navigation ability was similar across groups and unrelated to spatial navigation performance.ConclusionsThese findings suggest that allocentric navigation deficits in aMCI individuals are predominantly driven by AD pathology, independent of APOE genotype. This highlights the role of AD pathology as measured by biomarkers, rather than genetic status, as a major factor in navigational impairment in aMCI, and emphasizes the assessment of spatial navigation as a valuable tool for early detection of AD.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neurology

ISSN

0340-5354

e-ISSN

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Volume of the periodical

272

Issue of the periodical within the volume

6

Country of publishing house

DE - GERMANY

Number of pages

24

Pages from-to

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UT code for WoS article

001500448500001

EID of the result in the Scopus database

2-s2.0-105007289791