Impact of APOE and BDNF Val66Met gene polymorphisms on cognitive functions in patients with amnestic mild cognitive impairment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10395817" target="_blank" >RIV/00216208:11130/20:10395817 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/20:00072945 RIV/00064203:_____/20:10395817 RIV/00023884:_____/20:00008702

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Xi7NbsQKQ6" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Xi7NbsQKQ6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3233/JAD-190464" target="_blank" >10.3233/JAD-190464</a>

Result language

angličtina

Original language name

Impact of APOE and BDNF Val66Met gene polymorphisms on cognitive functions in patients with amnestic mild cognitive impairment

Original language description

Apolipoprotein (APOE) ε4 is a well-known risk factor for late-onset Alzheimer disease (AD), but other AD-related gene polymorphisms might also be important, such as polymorphisms within the brain-derived neurotrophic factor (BDNF) gene. Carriage of BDNF Val66Met has been associated with faster cognitive decline and greater hippocampal atrophy in cognitively normal elderly. We examined the effects of the concurrent presence of APOE and BDNF polymorphisms on cognitive functions and brain morphometry in amnestic mild cognitive impairment (aMCI) patients. 107 aMCI patients (mean age=72.2) were recruited from the Czech Brain Aging Study and based on APOE and BDNF genes polymorphisms were into 4 groups: ε4-BDNFVal/Val (n=37), ε4-BDNFMet (n=19), ε4+BDNFVal/Val (n=35), ε4+BDNFMet (n=16). All patients underwent clinical examination, magnetic resonance imaging and complex neuropsychological battery. Among BDNFMet carriers, we observed that APOE 4+ carriers performed worse than APOE 3 homozygotes in immediate and delayed recall. There was no difference in memory performance associated with APOE variation in BDNFVal homozygotes. We did not observe increased atrophy in areas related to memory function in the ε4+BDNFMet group. Our findings suggest that carriage of ε4+BDNFMet is associated with more pronounced memory dysfunction, which is typical feature for early AD, but not with structural brain changes in aMCI patients. These findings suggest that in APOE ε4/BDNF Met carriers, synaptic dysfunction affecting memory may precede pronounced structural changes.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Alzheimer&apos;s Disease

ISSN

1387-2877

e-ISSN

—

Volume of the periodical

73

Issue of the periodical within the volume

1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

11

Pages from-to

247-257

UT code for WoS article

000506311500020

EID of the result in the Scopus database

2-s2.0-85077802085