Homeobox gene expression in acute myeloid leukemia is linked to typical underlying molecular aberrations

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10293647" target="_blank" >RIV/00064203:_____/14:10293647 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/14:10293647
Result on the web
<a href="http://dx.doi.org/10.1186/s13045-014-0094-0" target="_blank" >http://dx.doi.org/10.1186/s13045-014-0094-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s13045-014-0094-0" target="_blank" >10.1186/s13045-014-0094-0</a>

Result language
angličtina
Original language name
Homeobox gene expression in acute myeloid leukemia is linked to typical underlying molecular aberrations
Original language description
Background: Although distinct patterns of homeobox (HOX) gene expression have been described in defined cytogenetic and molecular subsets of patients with acute myeloid leukemia (AML), it is unknown whether these patterns are the direct result of transcriptional alterations or rather represent the differentiation stage of the leukemic cell. Method: To address this question, we used qPCR to analyze mRNA expression of HOXA and HOXB genes in bone marrow (BM) samples of 46 patients with AML and sorted subpopulations of healthy BM cells. These various stages of myeloid differentiation represent matched counterparts of morphological subgroups of AML. To further study the transcriptional alterations of HOX genes in hematopoiesis, we also analyzed gene expression of epigenetic modifiers in the subpopluations of healthy BM and leukemic cells. Results: Unsupervised hierarchical clustering divided the AMLs into five clusters characterized by the presence of prevalent molecular genetic aberrations
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/GAP304%2F12%2F2214" target="_blank" >GAP304/12/2214: Transcription regulation of the HOX genes in normal and leukemic hematopoiesis</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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