Sox4 is a key oncogenic target in C/EBP alpha mutant acute myeloid leukemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F13%3A00422959" target="_blank" >RIV/68378050:_____/13:00422959 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.ccr.2013.09.018" target="_blank" >http://dx.doi.org/10.1016/j.ccr.2013.09.018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ccr.2013.09.018" target="_blank" >10.1016/j.ccr.2013.09.018</a>

Result language

angličtina

Original language name

Sox4 is a key oncogenic target in C/EBP alpha mutant acute myeloid leukemia

Original language description

Mutation or epigenetic silencing of the transcription factor C/EBP alpha is observed in similar to 10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but downstream targets relevant forleukemogenesis are not known. Here, we identify Sox4 as a direct target of C/EBP alpha whereby its expression is inversely correlated with C/EBP alpha activity. Downregulation of Sox4 abrogated increased self-renewal of leukemic cells and restored theirdifferentiation. Gene expression profiles of leukemia-initiating cells (LICs) from both Sox4 overexpression and murine C/EBP alpha mutant AML models clustered together but differed from other types of AML. Our data demonstrate that Sox4 overexpression resulting from C/EBP alpha inactivation contributes to the development of leukemia with a distinct LIC phenotype.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/LK21307" target="_blank" >LK21307: C/EBPg in normal hematopoiesis and acute myeloid leukemia: identification of the molecular mechanisms involved in cellular transformation</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer Cell

ISSN

1535-6108

e-ISSN

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Volume of the periodical

24

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

575-588

UT code for WoS article

000327005100006

EID of the result in the Scopus database

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