ZNF143 protein is an important regulator of the myeloid transcription factor C/EBP
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00486300" target="_blank" >RIV/68378050:_____/17:00486300 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/17:10373485
Result on the web
<a href="http://dx.doi.org/10.1074/jbc.M117.811109" target="_blank" >http://dx.doi.org/10.1074/jbc.M117.811109</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1074/jbc.M117.811109" target="_blank" >10.1074/jbc.M117.811109</a>
Alternative languages
Result language
angličtina
Original language name
ZNF143 protein is an important regulator of the myeloid transcription factor C/EBP
Original language description
The transcription factor C/EBP is essential for myeloid differentiation and is frequently dysregulated in acute myeloid leukemia. Although studied extensively, the precise regulation of its gene by upstream factors has remained largely elusive. Here, we investigated its transcriptional activation during myeloid differentiation. We identified an evolutionarily conserved octameric sequence, CCCAGCAG, approximate to 100 bases upstream of the CEBPA transcription start site, and demonstrated through mutational analysis that this sequence is crucial for C/EBP expression. This sequence is present in the genes encoding C/EBP in humans, rodents, chickens, and frogs and is also present in the promoters of other C/EBP family members. We identified that ZNF143, the human homolog of the Xenopus transcriptional activator STAF, specifically binds to this 8-bp sequence to activate C/EBP expression in myeloid cells through a mechanism that is distinct from that observed in liver cells and adipocytes. Altogether, our data suggest that ZNF143 plays an important role in the expression of C/EBP in myeloid cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biological Chemistry
ISSN
0021-9258
e-ISSN
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Volume of the periodical
292
Issue of the periodical within the volume
46
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
18924-18936
UT code for WoS article
000415848000017
EID of the result in the Scopus database
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