Early MRD response as a prognostic factor in adult patients with acute lymphoblastic leukemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10323716" target="_blank" >RIV/00064203:_____/16:10323716 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/16:00089256 RIV/00216208:11130/16:10323716 RIV/65269705:_____/16:00064628 RIV/00023736:_____/16:00011322
Result on the web
<a href="http://dx.doi.org/10.1111/ejh.12587" target="_blank" >http://dx.doi.org/10.1111/ejh.12587</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ejh.12587" target="_blank" >10.1111/ejh.12587</a>

Result language
angličtina
Original language name
Early MRD response as a prognostic factor in adult patients with acute lymphoblastic leukemia
Original language description
ObjectiveTo evaluate the prognostic power of minimal residual disease (MRD) monitored by polymerase chain reaction at defined time points during early treatment in adult patients with acute lymphoblastic leukemia (ALL). MethodsSeventy-one patients were treated according to the GMALL 07/2003 protocol and evaluated for MRD in bone marrow by specific clonal rearrangements of Ig/TCR in BCR-ABL negative ALL or fusion gene transcript in BCR-ABL positive ALL. ResultsThree-year overall survival (OS) was 94% in patients with BCR-ABL negative ALL reaching complete molecular response (CMR) after the first course of chemotherapy (vs. 32% if MRD >10(-4); P=0.001). Patients with CMR prior to the start of consolidation chemotherapy at week 11 had 3-yr OS 82% (vs. 18% if MRD >10(-4); P=0.001). Patients with BCR-ABL positive ALL showed slower MRD dynamics. There was a trend to better OS in patients with 4 log reduction of BCR-ABL transcript prior to HSCT (92% vs. 50%; P=0.065). None of the patients with detectable MRD (both BCR-ABL positive and negative) after HSCT survived 3yr. ConclusionEarly MRD kinetics is an important tool for new prognostication models with direct clinical impact irrespective of standard prognostic factors in patients with BCR-ABL negative ALL.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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