Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10323749" target="_blank" >RIV/00064203:_____/16:10323749 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/16:10323749
Result on the web
<a href="http://dx.doi.org/10.1007/s00345-015-1583-7" target="_blank" >http://dx.doi.org/10.1007/s00345-015-1583-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00345-015-1583-7" target="_blank" >10.1007/s00345-015-1583-7</a>
Alternative languages
Result language
angličtina
Original language name
Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma
Original language description
Purpose To evaluate risk factors for survival in a large international cohort of patients with primary urethral cancer (PUC). Methods A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death. Results Median age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p < 0.001) was noted. For clinical nodal staging, the corresponding sensitivity, specificity, and overall accuracy for predicting pathologic nodal stage were 92.8, 92.3, and 92.4 %, respectively. In multivariable Cox-regression analysis for patients staged cM0 at initial diagnosis, RFS was significantly associated with clinical nodal stage (p < 0.001), tumor location (p < 0.001), and age (p = 0.001), whereas clinical nodal stage was the only independent predictor for OS (p = 0.026). Conclusions These data suggest that clinical nodal stage is a critical parameter for outcomes in PUC.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
World Journal of Urology
ISSN
0724-4983
e-ISSN
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Volume of the periodical
34
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
97-103
UT code for WoS article
000369011200015
EID of the result in the Scopus database
2-s2.0-84954380501