Non-anaplastic peripheral T cell lymphoma in children and adolescents-an international review of 143 cases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10324714" target="_blank" >RIV/00064203:_____/16:10324714 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/16:00092588 RIV/00216208:11130/16:10324714 RIV/65269705:_____/16:00066091
Result on the web
<a href="http://dx.doi.org/10.1007/s00277-016-2722-y" target="_blank" >http://dx.doi.org/10.1007/s00277-016-2722-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00277-016-2722-y" target="_blank" >10.1007/s00277-016-2722-y</a>
Alternative languages
Result language
angličtina
Original language name
Non-anaplastic peripheral T cell lymphoma in children and adolescents-an international review of 143 cases
Original language description
Peripheral T cell lymphomas (PTCL) are rare in children and adolescents, and data about outcome and treatment results are scarce. The present study is a joint, international, retrospective analysis of 143 reported cases of non-anaplastic PTCL in patients < 19 years of age, with a focus on treatment and outcome features. One hundred forty-three patients, between 0.3 and 18.7 years old, diagnosed between 2000 and 2015 were included in the study. PTCL not otherwise specified was the largest subgroup, followed by extranodal NK/T cell lymphoma, hepatosplenic T cell lymphoma (HS TCL), and subcutaneous panniculitis-like T cell lymphoma (SP TCL). Probability of overall survival (pOS) at 5 years for the whole group was 0.56 +/- 0.05, and probability of event-free survival was (pEFS) 0.45 +/- 0.05. Patients with SP TCL had a good outcome with 5-year pOS of 0.78 +/- 0.1 while patients with HS TCL were reported with 5-year pOS of only 0.13 +/- 0.12. Twenty-five percent of the patients were reported to have a pre-existing condition, and this group had a dismal outcome with 5-year pOS of 0.29 +/- 0.09. The distribution of non-anaplastic PTCL subtypes in pediatric and adolescent patients differs from what is reported in adult patients. Overall outcome depends on the subtype with some doing better than others. Pre-existing conditions are frequent and associated with poor outcomes. There is a clear need for subtype-based treatment recommendations for children and adolescents with PTCL.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Annals of Hematology
ISSN
0939-5555
e-ISSN
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Volume of the periodical
95
Issue of the periodical within the volume
8
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
1295-1305
UT code for WoS article
000379189100010
EID of the result in the Scopus database
2-s2.0-84976260191