The Neutrophil-to-lymphocyte Ratio as a Prognostic Factor for Patients with Urothelial Carcinoma of the Bladder Following Radical Cystectomy: Validation and Meta-analysis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10336332" target="_blank" >RIV/00064203:_____/16:10336332 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/16:10336332

Result on the web

<a href="http://www.europeanurology.com/article/S2405-4569%2815%2900011-5/abstract/the-neutrophil-to-lymphocyte-ratio-as-a-prognostic-factor-for-patients-with-urothelial-carcinoma-of-the-bladder-following-radical-cystectomy-validation-and-meta-analysis" target="_blank" >http://www.europeanurology.com/article/S2405-4569%2815%2900011-5/abstract/the-neutrophil-to-lymphocyte-ratio-as-a-prognostic-factor-for-patients-with-urothelial-carcinoma-of-the-bladder-following-radical-cystectomy-validation-and-meta-analysis</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

The Neutrophil-to-lymphocyte Ratio as a Prognostic Factor for Patients with Urothelial Carcinoma of the Bladder Following Radical Cystectomy: Validation and Meta-analysis

Original language description

The neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic inflammatory response has been proposed as a prognostic factor for patients with urothelial carcinoma of the bladder (UCB) following radical cystectomy (RC).A high NLR (GREATER-THAN OR EQUAL TO2.7) was associated with advanced pathological tumor stages (p < 0.001), lymph node involvement (p < 0.001), lymphovascular invasion (p = 0.008), and positive soft0tissue surgical margins (p = 0.001). In multivariate analyses, a high NLR was independently associated with both OS (HR 1.11, 95% confidence interval [CI] 1.01-1.22; p = 0.029) and cancer-specific survival (CSS) (HR 1.21, 95% CI 1.07-1.37, p = 0.003). The discrimination of the multivariate models increased by 0.2% on inclusion of NLR. Five studies were included in the meta-analysis. The HR for NLR greater than the cutoff was 1.46 (95% CI 1.01-1.92) for OS and 1.51 (95% CI 1.17-1.85) for CSS. Limitations include the retrospective study design and the lack of standardized follow-up.In patients with UCB treated with RC, a high preoperative NLR is associated with more advanced tumor stage, lymph node metastasis, and worse prognosis. The NLR may be a readily available and useful biomarker for preoperative prognostic stratification.We investigated the neutrophil-to-lymphocyte ratio (NLR) as a prognostic marker in patients with bladder cancer treated with radical cystectomy. We found that a high NLR is associated with worse oncologic outcomes, suggesting it could play a role in risk stratification.A high neutrophil/lymphocyte ratio (NLR) seems to be associated with advanced pathologic tumor stages, lymph node involvement, lymphovascular invasion, positive soft-tissue surgical margins, and poorer overall survival and cancer-specific survival. NLR may become an adjunct to established prognostic markers for clinical decision-making, but further investigations are required.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Urology Focus

ISSN

2405-4569

e-ISSN

—

Volume of the periodical

2

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

79-85

UT code for WoS article

—

EID of the result in the Scopus database

—