Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10337222" target="_blank" >RIV/00064203:_____/16:10337222 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/16:10337222
Result on the web
<a href="http://dx.doi.org/10.1038/nn.4228" target="_blank" >http://dx.doi.org/10.1038/nn.4228</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/nn.4228" target="_blank" >10.1038/nn.4228</a>
Alternative languages
Result language
angličtina
Original language name
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
Original language description
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Neuroscience
ISSN
1097-6256
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
420-431
UT code for WoS article
000370822200014
EID of the result in the Scopus database
2-s2.0-84959158225