Analysis of shared heritability in common disorders of the brain
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376916" target="_blank" >RIV/00216208:11110/18:10376916 - isvavai.cz</a>
Alternative codes found
RIV/00023752:_____/18:43919405 RIV/00064165:_____/18:10376916
Result on the web
<a href="https://doi.org/10.1126/science.aap8757" target="_blank" >https://doi.org/10.1126/science.aap8757</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/science.aap8757" target="_blank" >10.1126/science.aap8757</a>
Alternative languages
Result language
angličtina
Original language name
Analysis of shared heritability in common disorders of the brain
Original language description
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science
ISSN
0036-8075
e-ISSN
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Volume of the periodical
360
Issue of the periodical within the volume
6395
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
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UT code for WoS article
000436040600034
EID of the result in the Scopus database
2-s2.0-85049284114