Adenoid hypertrophy affects screening for primary ciliary dyskinesia using nasal nitric oxide

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F18%3A10427539" target="_blank" >RIV/00064203:_____/18:10427539 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/18:10383417 RIV/00216208:11150/18:10383417 RIV/00179906:_____/18:10383417

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=QQKwcF7szq" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=QQKwcF7szq</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijporl.2018.09.007" target="_blank" >10.1016/j.ijporl.2018.09.007</a>

Result language

angličtina

Original language name

Adenoid hypertrophy affects screening for primary ciliary dyskinesia using nasal nitric oxide

Original language description

Aim: In patients with primary ciliary dyskinesia (PCD), the release of nitric oxide (NO) is extremely low by epithelia of the nasopharynx and sinuses. Measurement of nasal NO (nNO) is recommended as a screening test for PCD. The study aimed to evaluate if adenoids affects nNO and may deteriorate the performance of the test. Methods: In 48 nonallergic patients between 5 and 18 years of age with chronic symptoms of nasal obstruction and indications for adenoidectomy, the measurements of nNO by chemiluminescence analyser and nasal patency by active anterior rhinomanometry were performed both before and after adenoidectomy. Adenoidal tissue size was graded during surgery under general anaesthesia using transoral endoscopy. Results: Patients were stratified into groups with adenoids grades 1, 2 and 3 (&lt;1/3, 1/3-2/3 and &gt; 2/3 of the choana and post-nasal space covered by adenoids). Before adenoidectomy, the median of nNO decreased with the increasing grade of adenoids (920, 663, and 491 ppb, P &lt; 0.05). The rhinomanometry results were comparable and showed no correlation with nNO. Seven patients (14.6%) were incorrectly classified to have PCD based on a subthreshold value of the volume flow of nNO (FnNO &lt; 77 nL/min). Following adenoidectomy, nNO of the grade 3 patients increased by 107 ppb (P &lt; 0.05) and no differences were found between groups (P = 0.40). All patients had the postadenoidectomy FnNO &gt;77 nL/min. Conclusions: nNO and FnNO are reduced in nonallergic children with obstructive adenoids. Adenoid hypertrophy can potentially cause a false positive result of the test for PCD.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30206 - Otorhinolaryngology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Pediatric Otorhinolaryngology

ISSN

0165-5876

e-ISSN

—

Volume of the periodical

115

Issue of the periodical within the volume

December

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

4

Pages from-to

6-9

UT code for WoS article

000449898700002

EID of the result in the Scopus database

2-s2.0-85053524895