Adenoid hypertrophy affects screening for primary ciliary dyskinesia using nasal nitric oxide
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10383417" target="_blank" >RIV/00216208:11110/18:10383417 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/18:10383417 RIV/00179906:_____/18:10383417 RIV/00064203:_____/18:10427539
Result on the web
<a href="https://doi.org/10.1016/j.ijporl.2018.09.007" target="_blank" >https://doi.org/10.1016/j.ijporl.2018.09.007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijporl.2018.09.007" target="_blank" >10.1016/j.ijporl.2018.09.007</a>
Alternative languages
Result language
angličtina
Original language name
Adenoid hypertrophy affects screening for primary ciliary dyskinesia using nasal nitric oxide
Original language description
Aim: In patients with primary ciliary dyskinesia (PCD), the release of nitric oxide (NO) is extremely low by epithelia of the nasopharynx and sinuses. Measurement of nasal NO (nNO) is recommended as a screening test for PCD. The study aimed to evaluate if adenoids affects nNO and may deteriorate the performance of the test. Methods: In 48 nonallergic patients between 5 and 18 years of age with chronic symptoms of nasal obstruction and indications for adenoidectomy, the measurements of nNO by chemiluminescence analyser and nasal patency by active anterior rhinomanometry were performed both before and after adenoidectomy. Adenoidal tissue size was graded during surgery under general anaesthesia using transoral endoscopy. Results: Patients were stratified into groups with adenoids grades 1, 2 and 3 (<1/3, 1/3-2/3 and > 2/3 of the choana and post-nasal space covered by adenoids). Before adenoidectomy, the median of nNO decreased with the increasing grade of adenoids (920, 663, and 491 ppb, P < 0.05). The rhinomanometry results were comparable and showed no correlation with nNO. Seven patients (14.6%) were incorrectly classified to have PCD based on a subthreshold value of the volume flow of nNO (FnNO < 77 nL/min). Following adenoidectomy, nNO of the grade 3 patients increased by 107 ppb (P < 0.05) and no differences were found between groups (P = 0.40). All patients had the postadenoidectomy FnNO >77 nL/min. Conclusions: nNO and FnNO are reduced in nonallergic children with obstructive adenoids. Adenoid hypertrophy can potentially cause a false positive result of the test for PCD.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30206 - Otorhinolaryngology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Pediatric Otorhinolaryngology
ISSN
0165-5876
e-ISSN
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Volume of the periodical
115
Issue of the periodical within the volume
December
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
4
Pages from-to
6-9
UT code for WoS article
000449898700002
EID of the result in the Scopus database
2-s2.0-85053524895