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Adenoid hypertrophy affects screening for primary ciliary dyskinesia using nasal nitric oxide

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10383417" target="_blank" >RIV/00216208:11110/18:10383417 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11150/18:10383417 RIV/00179906:_____/18:10383417 RIV/00064203:_____/18:10427539

  • Result on the web

    <a href="https://doi.org/10.1016/j.ijporl.2018.09.007" target="_blank" >https://doi.org/10.1016/j.ijporl.2018.09.007</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.ijporl.2018.09.007" target="_blank" >10.1016/j.ijporl.2018.09.007</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Adenoid hypertrophy affects screening for primary ciliary dyskinesia using nasal nitric oxide

  • Original language description

    Aim: In patients with primary ciliary dyskinesia (PCD), the release of nitric oxide (NO) is extremely low by epithelia of the nasopharynx and sinuses. Measurement of nasal NO (nNO) is recommended as a screening test for PCD. The study aimed to evaluate if adenoids affects nNO and may deteriorate the performance of the test. Methods: In 48 nonallergic patients between 5 and 18 years of age with chronic symptoms of nasal obstruction and indications for adenoidectomy, the measurements of nNO by chemiluminescence analyser and nasal patency by active anterior rhinomanometry were performed both before and after adenoidectomy. Adenoidal tissue size was graded during surgery under general anaesthesia using transoral endoscopy. Results: Patients were stratified into groups with adenoids grades 1, 2 and 3 (&lt;1/3, 1/3-2/3 and &gt; 2/3 of the choana and post-nasal space covered by adenoids). Before adenoidectomy, the median of nNO decreased with the increasing grade of adenoids (920, 663, and 491 ppb, P &lt; 0.05). The rhinomanometry results were comparable and showed no correlation with nNO. Seven patients (14.6%) were incorrectly classified to have PCD based on a subthreshold value of the volume flow of nNO (FnNO &lt; 77 nL/min). Following adenoidectomy, nNO of the grade 3 patients increased by 107 ppb (P &lt; 0.05) and no differences were found between groups (P = 0.40). All patients had the postadenoidectomy FnNO &gt;77 nL/min. Conclusions: nNO and FnNO are reduced in nonallergic children with obstructive adenoids. Adenoid hypertrophy can potentially cause a false positive result of the test for PCD.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30206 - Otorhinolaryngology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Pediatric Otorhinolaryngology

  • ISSN

    0165-5876

  • e-ISSN

  • Volume of the periodical

    115

  • Issue of the periodical within the volume

    December

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    4

  • Pages from-to

    6-9

  • UT code for WoS article

    000449898700002

  • EID of the result in the Scopus database

    2-s2.0-85053524895