Predicting Outcomes in Pediatric Ulcerative Colitis for Management Optimization: Systematic Review and Consensus Statements from PIBD-Ahead Program
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F21%3A10415909" target="_blank" >RIV/00064203:_____/21:10415909 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/21:10415909
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9b8QPj80jc" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9b8QPj80jc</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1053/j.gastro.2020.07.066" target="_blank" >10.1053/j.gastro.2020.07.066</a>
Alternative languages
Result language
angličtina
Original language name
Predicting Outcomes in Pediatric Ulcerative Colitis for Management Optimization: Systematic Review and Consensus Statements from PIBD-Ahead Program
Original language description
BACKGROUND AND AIMS: A better understanding of prognostic factors in ulcerative colitis (UC) could improve patient management and reduce complications. We aimed to identify evidence-based predictors for outcomes in pediatric UC, which may be used to optimize treatment algorithms. METHODS: Potential outcomes worthy of prediction in UC were determined by surveying 202 experts in pediatric UC. A systematic review of the literature, with selected meta-analysis, was performed to identify studies that investigated predictors for these outcomes. Multiple national and international meetings were held to reach consensus on evidence-based statements. RESULTS: Consensus was reached on 31 statements regarding predictors of colectomy, acute severe colitis (ASC), chronically active pediatric UC, and cancer or mortality. At diagnosis, disease extent (six studies, n=627; P=.035), Pediatric Ulcerative Colitis Activity Index (PUCAI) score (four studies, n=318; P<.001), hemoglobin, hematocrit, and albumin may predict colectomy. In addition, family history of UC (two studies, n=557; P=.0004), extraintestinal manifestations (four studies, n=526; P=.048), and disease extension over time may predict colectomy, while primary sclerosing cholangitis (PSC) may be protective. ASC may be predicted by disease severity at onset and hypoalbuminemia. Higher PUCAI score and C-reactive protein on day 3 and 5 of hospital admission predict failure of intravenous steroids. Risk factors for malignancy included concomitant diagnosis of PSC, longstanding colitis (>10 years), male sex, younger age at diagnosis, and thiopurine use. CONCLUSIONS: These evidence-based consensus statements offer predictions to be considered for a personalized medicine approach in treating pediatric UC.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30219 - Gastroenterology and hepatology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Gastroenterology
ISSN
0016-5085
e-ISSN
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Volume of the periodical
160
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
25
Pages from-to
378-402
UT code for WoS article
000600644700046
EID of the result in the Scopus database
2-s2.0-85097458553