An unusual fusion gene EML4-ALK in a patient with congenital mesoblastic nephroma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F21%3A10429919" target="_blank" >RIV/00064203:_____/21:10429919 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/21:10429919
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Eit0flynJE" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Eit0flynJE</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/gcc.22990" target="_blank" >10.1002/gcc.22990</a>
Alternative languages
Result language
angličtina
Original language name
An unusual fusion gene EML4-ALK in a patient with congenital mesoblastic nephroma
Original language description
Congenital mesoblastic nephroma (CMN), the most common renal tumor of infancy, is a mesenchymal neoplasm histologically classified into classic, cellular, or mixed types. Most cellular CMNs harbor a characteristic ETV6-NTRK3 fusion. Here we report an unusual congenital mesoblastic nephroma presenting in a newborn boy with a novel EML4-ALK gene fusion revealed by Anchored Multiplex RNA Sequencing Assay. The EML4-ALK gene fusion expands the genetic spectrum implicated in the pathogenesis of congenital mesoblastic nephroma, with yet another example of kinase oncogenic activation through chromosomal rearrangement. The methylation profile of the tumor corresponds with infantile fibrosarcoma showing the biological similarity of these two entities.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Genes, Chromosomes & Cancer
ISSN
1045-2257
e-ISSN
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Volume of the periodical
60
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
837-840
UT code for WoS article
000687020000001
EID of the result in the Scopus database
2-s2.0-85113521869