Repeatability of lung clearance index in infants with cystic fibrosis and recurrent wheeze
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F22%3A10443000" target="_blank" >RIV/00064203:_____/22:10443000 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/22:10443000 RIV/00216208:11320/22:10443000
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Jp6KdlsRkX" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Jp6KdlsRkX</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ppul.25921" target="_blank" >10.1002/ppul.25921</a>
Alternative languages
Result language
angličtina
Original language name
Repeatability of lung clearance index in infants with cystic fibrosis and recurrent wheeze
Original language description
OBJECTIVES: To describe the short- and medium-term repeatability of lung clearance index (LCI(2.5) ) in infants and calculate the number of patients needed to enrol in a study (N) using LCI(2.5) as a primary outcome. METHODS: An 8-month follow-up observational study was employed for assessing short-term [coefficient of repeatability (CR) and intraclass correlation (ICC)] and medium-term repeatability (Bland-Altman method) of LCI(2.5) in infants with cystic fibrosis (CF) or recurrent wheeze (RW) measured by the nitrogen multiple-breath washout test (N(2) -MBW). Using these variability data, the N to reach 90% test power at the level of statistical significance (0.05) was calculated. RESULTS: Forty infants with CF and 21 with RW were enrolled. Initial N(2) -MBW testing was successful in 33 and 17 patients, respectively. Follow-up data were available for 23 and 11 infants, respectively. Short-term repeatability of LCI(2.5) was high (CR = 1.10 and 1.04 in CF and RW patients, respectively; ICC = 0.88 and 0.83 in CF and RW patients, respectively). The between-subject standard deviation was <13% of the actual LCI(2.5) value. In clinically stable patients, LCI(2.5) did not significantly change during the 8-month follow-up. Mean LCI(2.5) change was -0.08 (1% of baseline) in CF and -0.05 (0.6%) in RW, with 95% limits of agreement being (-1.70; 1.53) in CF and (-1.51; 1.40) in RW patients. N = 23 infants if both intra-group differences of LCI(2.5) and minimal difference to be detected would be 2.0. CONCLUSION: N(2) -MBW may be a reproducible tool with reasonable test power to detect differences in infant studies. This article is protected by copyright. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pediatric Pulmonology [online]
ISSN
1099-0496
e-ISSN
1099-0496
Volume of the periodical
57
Issue of the periodical within the volume
7
Country of publishing house
BD - BANGLADESH
Number of pages
10
Pages from-to
1608-1617
UT code for WoS article
000787387500001
EID of the result in the Scopus database
2-s2.0-85128745795