Reflex zone stimulation reduces ventilation inhomogeneity in cystic fibrosis: A randomised controlled cross-over study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F21%3A10425319" target="_blank" >RIV/00064203:_____/21:10425319 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/21:10425319
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=5riLQnqErw" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=5riLQnqErw</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ppul.25350" target="_blank" >10.1002/ppul.25350</a>
Alternative languages
Result language
angličtina
Original language name
Reflex zone stimulation reduces ventilation inhomogeneity in cystic fibrosis: A randomised controlled cross-over study
Original language description
BACKGROUND: The reflex zone stimulation technique (RST) activates complex motor responses and has a positive impact on the locomotor system. This technique may also indirectly affect breathing; however, the use of this technique as adjunct of the treatment of cystic fibrosis (CF) has not yet been characterised. METHODS: We performed a randomised controlled single-centre interventional trial to evaluate the short-term effects of RST on lung function in 21 paediatric CF patients with normal baseline spirometry. The effect of 30 minutes of RST was compared to that of sham therapy in a crossover design. The interventions were performed in random order and planned 6 months apart. The primary outcome was a change in global ventilation inhomogeneity after intervention, assessed by lung clearance index (LCI(2.5) ) derived from a nitrogen multiple breath washout test. Secondary outcomes included changes in regional ventilation inhomogeneity (indices of acinar [Sacin*Vt] and conductive airway [Scond*Vt] inhomogeneity) and spirometry parameters (inspiratory capacity, forced vital capacity, and forced expiratory volume in 1 second). Trunk deformity was assessed by physiotherapists at study entry. RESULTS: After the RST intervention, the LCI(2.5) (p = 0.004) and Scond*Vt (p = 0.009) decreased significantly, while inspiratory capacity increased (p = 0.012). In the sham-therapy group, none of the parameters changed significantly. Trunk deformity was seen in 76.5% of all patients, and 92.9% of those with trunk deformity showed a decrease in LCI(2.5) after RST. CONCLUSION: RST has multiple positive short-term effects on lung function, especially in CF patients with trunk deformities. This article is protected by copyright. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30203 - Respiratory systems
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pediatric Pulmonology [online]
ISSN
1099-0496
e-ISSN
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Volume of the periodical
56
Issue of the periodical within the volume
6
Country of publishing house
BD - BANGLADESH
Number of pages
8
Pages from-to
1558-1565
UT code for WoS article
000628390000001
EID of the result in the Scopus database
2-s2.0-85102474466