Baseline reticular basement membrane morphology is related to subsequent spirometry deterioration in pediatric chronic airway inflammation: A follow-up study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F23%3A10464879" target="_blank" >RIV/00064203:_____/23:10464879 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/23:10464879 RIV/00216208:11320/23:10464879
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=qoiwC65q4h" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=qoiwC65q4h</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1152/ajplung.00058.2023" target="_blank" >10.1152/ajplung.00058.2023</a>
Alternative languages
Result language
angličtina
Original language name
Baseline reticular basement membrane morphology is related to subsequent spirometry deterioration in pediatric chronic airway inflammation: A follow-up study
Original language description
Reticular basement membrane (RBM) thickening may occur in children with allergic bronchial asthma (BA), cystic fibrosis (CF), and primary ciliary dyskinesia (PCD). Its functional consequences remain unknown. We investigated the relationship between baseline RBM thickness and subsequent spirometry. In our cohort follow-up study, patients aged 3-18 years with BA, CF, and PCD and controls underwent baseline lung clearance index (LCI) measurement, spirometry, and endobronchial biopsy sampling. Total RBM and collagen IV-positive layer thickness were measured. Trends in forced vital capacity (FVC), forced expired volume in 1 second (FEV(1)), and FEV(1)/FVC were analyzed during follow-up, and their relationship to baseline characteristics was studied using univariate analysis and multiple regression models. Complete baseline data were available in 19 BA, 30 CF, 25 PCD patients, and 19 controls. The RBM was thicker in BA (6.33+-1.22 μm), CF (5.60+-1.39 μm), and PCD (6.50+-1.87 μm) than in controls (3.29+-0.55 μm) (all p<0.001). The LCI was higher in CF (15.32+-4.58, p<0.001) and PCD (10.97+-2.46, p=0.002) than in controls (7.44+-0.43). The median follow-up times were 3.6, 4.8, 5.7, and 1.9 years in BA, CF, PCD, and controls respectively. The Z-scores of FEV(1) and FEV(1)/FVC deteriorated significantly in all groups except in controls. In CF and PCD, trends in FEV(1) z-scores correlated with baseline LCI and RBM; in BA, it correlated with collagen IV. In multiple regression models, RBM morphology and ventilation inhomogeneity could predict up to 84.4% of variability in spirometry trends. In conclusion, baseline LCI value and RBM morphology may predict trends in subsequent spirometry.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Physiology - Lung Cellular and Molecular Physiology
ISSN
1040-0605
e-ISSN
1522-1504
Volume of the periodical
325
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
"L125"-"L134"
UT code for WoS article
001034287400004
EID of the result in the Scopus database
2-s2.0-85164625268