Longitudinal tracking of muscle sympathetic nerve activity and its relationship with blood pressure in subjects with prehypertension

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00068461" target="_blank" >RIV/00159816:_____/16:00068461 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3109/08037051.2015.1121708" target="_blank" >http://dx.doi.org/10.3109/08037051.2015.1121708</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/08037051.2015.1121708" target="_blank" >10.3109/08037051.2015.1121708</a>

Result language

angličtina

Original language name

Longitudinal tracking of muscle sympathetic nerve activity and its relationship with blood pressure in subjects with prehypertension

Original language description

Prehypertension is associated with increased cardiovascular events. While the tracking phenomenon is an important longitudinal characteristic of blood pressure (BP), changes in muscle sympathetic nerve activity (MSNA) over time remain unclear. This study tested the hypothesis that MSNA tracking contributes to BP trends in prehypertension. BP and MSNA were assessed in 13 prehypertensive males at rest, during hand grip and mental stressors at baseline and after 8 years. Baseline office BP averaged 127 +/- 2/81 +/- 2 mmHg and MSNA 24 +/- 4 bursts/min. BP increased by 7 +/- 2/5 +/- 2 mmHg (P&lt;0.01) and MSNA by 11 +/- 2 bursts/min (P&lt;0.001) at follow-up. SBP and DBP were interrelated at baseline (r=0.65, P=0.02) and at follow-up (r=0.78, P=0.002). MSNA tracking (r=0.82; P&lt;0.001) was similar to BP. MSNA was strongly related to DBP at baseline (r=0.73; P&lt;0.01) and follow-up (r=0.64; P=0.01), more so than SBP. BMI increased (P&lt;0.001) at follow-up but was unrelated to BP or MSNA. Despite comparable pressor and cardiac increases to handgrip and mental stressors, sympathetic responses were blunted, more pronounced to isometric test (P&lt;0.006) at follow-up. In conclusion, the trend in MSNA corresponds with BP changes over time suggesting that tonic sympathetic activation may contribute to time-related increase in resting BP and the development of sustained hypertension in prehypertension.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Blood pressure

ISSN

0803-7051

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

184-192

UT code for WoS article

000377030300009

EID of the result in the Scopus database

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