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Current management in the treatment of intramedullary ependymomas in children

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F23%3A10452774" target="_blank" >RIV/00064203:_____/23:10452774 - isvavai.cz</a>

  • Alternative codes found

    RIV/61383082:_____/23:00001299 RIV/00216208:11130/23:10452774 RIV/00216208:11110/23:10452774

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=37uETSPoG" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=37uETSPoG</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00381-022-05814-y" target="_blank" >10.1007/s00381-022-05814-y</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Current management in the treatment of intramedullary ependymomas in children

  • Original language description

    Purpose: Current management of pediatric intramedullary ependymoma is extrapolated from adult series since large studies in children are unavailable. This has led us to share our experience with this rare tumor and compare it to the literature and to review and highlight important aspects of current management and point out inconsistencies. Methods: This is a retrospective analysis of patients with intramedullary ependymoma managed at our institution between 2004 and 2021. Results: During the study period, 5 patients were treated for intramedullary ependymoma. Cases of myxopapillary ependymoma were excluded. The mean age of our cohort was 11.2 years. We identified 4 cases of grade II ependymoma and 1 case of grade III ependymoma. Gross tumor removal (GTR) was achieved in two patients (40%) of patients. One patient was treated with radiotherapy for recurrence and two patients received chemotherapy. There were no cases of recurrence among patients treated with GTR, but in all patients treated with STR. Eighty percent of patients either improved or stayed stable neurologically. During follow-up (mean 73 months), 2 patients died of disease. Conclusion: GTR and tumor grade remain the key prognostic factor of long-term tumor-free survival. Many questions prevail regarding outcomes, correct use of adjuvant therapy, and prognostic factors.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30103 - Neurosciences (including psychophysiology)

Result continuities

  • Project

    <a href="/en/project/NU21-07-00419" target="_blank" >NU21-07-00419: Unique molecular biology of paediatric brain tumours associated with cancer predisposition syndromes</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Child&apos;s Nervous System

  • ISSN

    0256-7040

  • e-ISSN

  • Volume of the periodical

    39

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    10

  • Pages from-to

    1183-1192

  • UT code for WoS article

    000904938900001

  • EID of the result in the Scopus database

    2-s2.0-85144901217