Effect of two additional doses of intrathecal methotrexate during induction therapy on serious infectious toxicity in pediatric patients with acute lymphoblastic leukemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F23%3A10458588" target="_blank" >RIV/00064203:_____/23:10458588 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/23:10458588
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=wMpEgMXIFf" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=wMpEgMXIFf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3324/haematol.2022.281788" target="_blank" >10.3324/haematol.2022.281788</a>

Result language
angličtina
Original language name
Effect of two additional doses of intrathecal methotrexate during induction therapy on serious infectious toxicity in pediatric patients with acute lymphoblastic leukemia
Original language description
Although initial central nervous system (CNS) involvement is rarely detected in childhood acute lymphoblastic leukemia (ALL), risk-adapted CNS-directed therapy is essential for all patients. Treatment intensity depends on the initial CNS status. In trial AIEOP-BFM ALL 2009, patients with cytomorphological detection of leukemic blasts in initial cerebrospinal fluid were classified as CNS2 or CNS3 and received five intrathecal doses of methotrexate in induction therapy compared to patients with CNS1 status (no blasts detected) who received three doses. The impact of additional intrathecal methotrexate on systemic toxicity in induction therapy is unknown. Between June 01, 2010 and February 28, 2017, 6136 patients at the age of 1 to 17 years with ALL were enrolled onto the trial AIEOP-BFM ALL 2009. The effect of three versus five doses of intrathecal methotrexate during induction therapy on the incidence of severe infectious complications was analyzed. Among 4706 patients treated with three intrathecal methotrexate doses, 77 (1.6%) had a lifethreatening infection during induction as compared to 59 of 1350 (4.4%) patients treated with five doses (p.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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