Similar immune responses to alpha1-oleate and Bacillus Calmette-Guérin treatment in patients with bladder cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F24%3A10479108" target="_blank" >RIV/00064203:_____/24:10479108 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/24:10479108
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=oZH5MmWscC" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=oZH5MmWscC</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cam4.7091" target="_blank" >10.1002/cam4.7091</a>
Alternative languages
Result language
angličtina
Original language name
Similar immune responses to alpha1-oleate and Bacillus Calmette-Guérin treatment in patients with bladder cancer
Original language description
BackgroundThe molecular content of urine is defined by filtration in the kidneys and by local release from tissues lining the urinary tract. Pathological processes and different therapies change the molecular composition of urine and a variety of markers have been analyzed in patients with bladder cancer. The response to BCG immunotherapy and chemotherapy has been extensively studied and elevated urine concentrations of IL-1RA, IFN-alpha, IFN-gamma TNF-alpha, and IL-17 have been associated with improved outcome.MethodsIn this study, the host response to intravesical alpha 1-oleate treatment was characterized in patients with non-muscle invasive bladder cancer by proteomic and transcriptomic analysis.ResultsProteomic profiling detected a significant increase in multiple cytokines in the treatment group compared to placebo. The innate immune response was strongly activated, including IL-1RA and pro-inflammatory cytokines in the IL-1 family (IL-1 alpha, IL-1 beta, IL-33), chemokines (MIP-1 alpha, IL-8), and interferons (IFN-alpha 2, IFN-gamma). Adaptive immune mediators included IL-12, Granzyme B, CD40, PD-L1, and IL-17D, suggesting broad effects of alpha 1-oleate treatment on the tumor tissues.ConclusionsThe cytokine response profile in alpha 1-oleate treated patients was similar to that reported in BCG treated patients, suggesting a significant overlap. A reduction in protein levels at the end of treatment coincided with inhibition of cancer-related gene expression in tissue biopsies, consistent with a positive treatment effect. Thus, in addition to killing tumor cells and inducing cell detachment, alpha 1-oleate is shown to activate a broad immune response with a protective potential.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30217 - Urology and nephrology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Medicine
ISSN
2045-7634
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
20
Pages from-to
e7091
UT code for WoS article
001203117400004
EID of the result in the Scopus database
2-s2.0-85189495519