PAX5::AUTS2 childhood B-ALL: a relapse-prone genetic subtype with frequent central nervous system involvement and a poor outcome: ACUTE LYMPHOBLASTIC LEUKEMIA

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10489510" target="_blank" >RIV/00064203:_____/25:10489510 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/25:10489510
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=nE24Cuh0mc" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=nE24Cuh0mc</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41375-024-02502-5" target="_blank" >10.1038/s41375-024-02502-5</a>

Result language
angličtina
Original language name
PAX5::AUTS2 childhood B-ALL: a relapse-prone genetic subtype with frequent central nervous system involvement and a poor outcome: ACUTE LYMPHOBLASTIC LEUKEMIA
Original language description
In childhood and young adolescent B-cell precursor acute lymphoblastic leukemia (B-ALL) PAX5 is one of the most frequent targets of genetic alterations comprising deletions, intragenic amplifications (PAX5AMP), and point mutations as well as rearrangements (PAX5-r) with multiple partner genes. PAX5-r account for 2-3% of all newly diagnosed B-ALL cases and result in the expression of fusion oncoproteins. Patients with PAX5-r tend to have higher relapse and poorer overall survival (OS) rates compared to good-risk genetic groups. Most, but not all, cases with PAX5-r belong to the PAX5-altered (PAX5alt) subtype identified by gene expression profiling. PAX5alt is associated with an intermediate to poor prognosis with a strong dependence on IKZF1 codeletion.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology

Project
<a href="/en/project/EH22_008%2F0004644" target="_blank" >EH22_008/0004644: Saving lives through research in early cancer detection and prevention: Molecular, genomic and societal factors</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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