Comparable outcomes in single versus multiple septal branches alcohol ablation for obstructive hypertrophic cardiomyopathy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10495913" target="_blank" >RIV/00064203:_____/25:10495913 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/25:10495913 RIV/00216208:11310/25:10495913
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8TCQuwpE71" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8TCQuwpE71</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijcard.2025.133145" target="_blank" >10.1016/j.ijcard.2025.133145</a>
Alternative languages
Result language
angličtina
Original language name
Comparable outcomes in single versus multiple septal branches alcohol ablation for obstructive hypertrophic cardiomyopathy
Original language description
BACKGROUND: The optimal number of septal branches to target during initial alcohol septal ablation (ASA) for hypertrophic obstructive cardiomyopathy (HOCM) remains a subject of debate. It is unclear whether to proceed with ASA of additional septal branches if a satisfactory hemodynamic effect has not been achieved following ablation of the first branch. METHODS: Using propensity score matching analysis, we compared patients who achieved satisfactory outcomes after ASA of a single septal branch with those in whom additional branches were ablated. RESULTS: A total of 457 patients were included in the study, with a median follow-up of 5.61 years (interquartile range 2.08-10.91 years). Propensity score matching identified 92 pairs (184 patients), divided into the single-ablated-branch and more-ablated-branches groups. No significant differences were found in the incidence of major cardiovascular adverse events within the first 30 days between the two groups. Similarly, there were no differences in long-term outcomes between the matched single-ablated-branch and multiple-ablated-branches groups regarding all-cause mortality (3.77 vs.2.90 deaths per 100 patient-years, log-rank p = 0.649), re-intervention rates (12 % vs. 8 %; log-rank p = 0.345), left ventricular outflow gradient (14 +- 13 mmHg vs. 16 +- 15 mmHg; p = 0.209), or NYHA functional class (1.7 +- 0.6 vs. 1.6 +- 0.7; p = 0.629). CONCLUSIONS: In both short- and long-term follow-ups, ASA targeting single or multiple septal branches showed comparable efficacy and safety in patients with hypertrophic obstructive cardiomyopathy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Cardiology
ISSN
0167-5273
e-ISSN
1874-1754
Volume of the periodical
429
Issue of the periodical within the volume
June
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
5
Pages from-to
133145
UT code for WoS article
001449123100001
EID of the result in the Scopus database
2-s2.0-86000626399