Outcomes of Alcohol Septal Ablation in Patients with Severe Left Ventricular Outflow Tract Obstruction: A Propensity Score Matching Analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F23%3A10465380" target="_blank" >RIV/00064203:_____/23:10465380 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/23:10465380 RIV/00216208:11310/23:10465380
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9iU63gbzZ5" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9iU63gbzZ5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cjca.2023.06.417" target="_blank" >10.1016/j.cjca.2023.06.417</a>
Alternative languages
Result language
angličtina
Original language name
Outcomes of Alcohol Septal Ablation in Patients with Severe Left Ventricular Outflow Tract Obstruction: A Propensity Score Matching Analysis
Original language description
BACKGROUND: The current ACC/AHA guidelines on hypertrophic cardiomyopathy (HCM) caution that alcohol septal ablation (ASA) might be less effective in patients with left ventricular outflow tract obstruction (LVOTO) >=100 mmHg.METHODS: We used a multinational registry to evaluate the outcome of ASA patients according to baseline LVOTO.RESULTS: A total of 1346 ASA patients were enrolled and followed for 5.8+-4.7 years (7764 patient-years). The patients with baseline LVOTO >=100 mmHg were significantly older (61+-14 years vs. 57+-13 years; p<0.01), more often women (60% vs. 45%; p<0.01), and had a more pronounced HCM phenotype than those with baseline LVOTO <100 mmHg. There were no significant differences in the occurrences of 30-day major cardiovascular adverse events in the two groups. After propensity score matching (2 groups, 257 pairs of patients), the long-term survival was similar in both groups (p=0.10), the relative reduction of LVOTO was higher in the group with the baseline LVOTO >=100 mmHg (82+-21% vs. 73+-26%; p<0.01), but the residual resting LVOTO remained higher in this group (23+-29 mmHg vs. 13+-13 mmHg; p<0.01). Dyspnea (NYHA class) at the most recent clinical check-up was similar in both groups (1.7+-0.7 vs. 1.7+-0.7; p=0.85), and patients with baseline LVOTO >=100 mmHg underwent more re-interventions (p=0.02).CONCLUSIONS: After propensity matching, ASA patients with baseline LVOTO >=100 mmHg had similar survival and dyspnea (NYHA class) as patients with baseline LVOTO <100 mmHg but their residual LVOTO and risk of repeated procedures were higher.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Canadian Journal of Cardiology
ISSN
0828-282X
e-ISSN
1916-7075
Volume of the periodical
39
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
1622-1629
UT code for WoS article
001111502700001
EID of the result in the Scopus database
2-s2.0-85173219425