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Patients with hypertrophic obstructive cardiomyopathy after alcohol septal ablation have favorable long-term outcome irrespective of their genetic background

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10410735" target="_blank" >RIV/00216208:11130/20:10410735 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064203:_____/20:10410735

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WKpc367Ujp" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WKpc367Ujp</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.21037/cdt.2020.01.12" target="_blank" >10.21037/cdt.2020.01.12</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Patients with hypertrophic obstructive cardiomyopathy after alcohol septal ablation have favorable long-term outcome irrespective of their genetic background

  • Original language description

    Background: The genetic background of patients with hypertrophic cardiomyopathy (HCM) treated with alcohol septal ablation (ASA) and its relationship to the outcomes are not known. We aimed to investigate whether the outcome of genotype positive (G+) patients differs from genotype negative (G-) patients treated with ASA. Methods: We included 129 HCM patients (mean age 54 +/- 13 years) treated with ASA in a tertiary cardiovascular center and performed next generation sequencing (NGS) based genomic testing. All patients were followed-up three months after the procedure and yearly thereafter. Results: A total of 30 (23%) HCM patients were G+ patients. At the 3-months follow-up, both groups of patients had similar left ventricular outflow tract PG (16.9 +/- 15.7 mmHg in G+ vs. 16.3 +/- 18.8 mmHg in G-, P=0.73) and symptoms (follow-up NYHA class 1.40 +/- 0.62 vs. 1.37 +/- 0.53, P=0.99, follow-up CCS class 0.23 +/- 0.52 vs. 0.36 +/- 0.65, P=0.36). The independent predictors of all-cause mortality were baseline interventricular septum (IVS) thickness (HR 1.12, 95% CI: 1.00-1.26, P=0.049) and age at the time of ASA (HR 1.11, 95% CI: 1.06-1.17, P&lt;0.01). The adjusted all-cause mortality rate did not differ significantly between G+ and G- patients (P=0.52). The adjusted combined mortality event rate did not differ between both groups (P=0.78). Conclusions: Despite more severe phenotype in G+ HCM patients, ASA is an equally effective treatment for LVOTO in G+ patients as it is for treating LVOTO in G- patients. The long-term outcome after ASA is similar in G+ and G- patients.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30201 - Cardiac and Cardiovascular systems

Result continuities

  • Project

    <a href="/en/project/NV15-34904A" target="_blank" >NV15-34904A: Next generation sequencing for early diagnosis and individualized therapy of hypertrophic cardiomyopathy</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cardiovascular Diagnosis and Therapy

  • ISSN

    2223-3652

  • e-ISSN

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    CN - CHINA

  • Number of pages

    8

  • Pages from-to

    193-200

  • UT code for WoS article

    000528262000010

  • EID of the result in the Scopus database

    2-s2.0-85085984325