Obstruction after alcohol septal ablation is associated with cardiovascular mortality events
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10332735" target="_blank" >RIV/00064203:_____/16:10332735 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/16:00091205 RIV/00216208:11130/16:10332735 RIV/00159816:_____/16:00065578
Result on the web
<a href="http://dx.doi.org/10.1136/heartjnl-2016-309699" target="_blank" >http://dx.doi.org/10.1136/heartjnl-2016-309699</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/heartjnl-2016-309699" target="_blank" >10.1136/heartjnl-2016-309699</a>
Alternative languages
Result language
angličtina
Original language name
Obstruction after alcohol septal ablation is associated with cardiovascular mortality events
Original language description
Background Left ventricular outflow tract obstruction (>= 30 mm Hg at rest; LVOTO) is considered a possible risk of long-term outcomes in patients with hypertrophic cardiomyopathy (HCM). However, the influence of LVOTO on the occurrence of cardiovascular mortality events in patients after alcohol septal ablation (ASA) for obstructive HCM remains unresolved. Methods We compared the outcomes of patients treated with ASA with residual LVOTO < 30 mm Hg with those with residual LVOTO >= 30 mm Hg at the first postdischarge check-up (1-6 months after the procedure). Results A total of 270 patients (60 +/- 12 years, median follow-up 5.1 years; 95% CI 4.5 to 5.9 years) treated with a single ASA were included; 208 (77%) and 62 (23%) patients had post-ASA LVOTO < 30 and >= 30 mm Hg at the first postdischarge clinical check-up, respectively (LVOTO 13 +/- 6 vs 50 +/- 27 mm Hg; p<0.01). Freedom from cardiovascular mortality events at 1, 5 and 10 years were 99% (95% CI 96% to 100%) vs 94% (95% CI 85% to 98%), 95% (95% CI 89% to 97%) vs 80% (95% CI 66% to 89%) and 82% (95% CI 69% to 89%) vs 72% (95% CI 55% to 84%) (log-rank test, p<0.01), respectively. In multivariable analysis adjusted for age at ASA, sex, baseline LVOTO and baseline septum thickness, the independent predictors of cardiovascular mortality events were early postdischarge LVOTO >= 30 mm Hg (HR 2.95, 95% CI 1.26 to 6.91; p=0.01) and baseline septum thickness (HR 1.07, 95% CI 1.01 to 1.13; p=0.02). Conclusions After ASA for obstructive HCM, LVOTO >= 30 mm Hg at the first postdischarge clinical check-up is associated with significantly higher occurrence of subsequent cardiovascular mortality events.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NV15-34904A" target="_blank" >NV15-34904A: Next generation sequencing for early diagnosis and individualized therapy of hypertrophic cardiomyopathy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Heart
ISSN
1355-6037
e-ISSN
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Volume of the periodical
102
Issue of the periodical within the volume
22
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
1793-1796
UT code for WoS article
000387065200007
EID of the result in the Scopus database
2-s2.0-84984972832